Dr Abby Dolan was on the fast track at a major San Francisco hospital when she made a critical choice: to follow her fiance, Josh Wyler, to the picturesque California town of Patience, where he has a new job with the manufacturing giant Colstar. Working in a small-town emergency room, knowing her every move sparks gossip, Abby nonetheless begins to feel at home - until the first undiagnosable patients start to showing up. Abby calls them NIWWs: No Idea What's Wrong. And despite her considerable skills, she can, track these baffling, seemingly random cases. When Josh too begins to suffer disturbing symptoms, followed by manic, even violent behaviour, she wonders: Could Colstar somehow be poisoning the town? Warned by a colleague that her predecessor in the ER died in a dubious accident after making similar allegations, Abby refuses to back off. She begins to question everyone and everything around her in the now hostile town of patience - while her most dangerous enemy is far closer than she thinks.