This book is a concise, easy-to read guide to a selection of the most important contemporary electrophysiological techniques, their implementation, applications, and ways in which they can be combined and integrated with related neuroscience techniques. It is intended for students, postdocs and faculty with a basic neuroscience background, so does not obscure the relevant technical details with textbook neuroscience tutorials as many other books do. Each chapter provides a concise overview of the underlying theory, a comprehensive description of equipment, materials, methods, data management and analysis, a troubleshooting guide, and a list of frequently asked questions. No book or online resource can function as a strictly DIY set of instructions on how to implement a complex technique. However, this book provides a fundamental and accessible set of information intended to form a foundation prior to, during, and after hands-on experience and training, greatly facilitating the initial learning process and subsequent fine-tuning of technical details.