Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models (Innbundet)

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Forfatter: og
Innbinding: Innbundet
Utgivelsesår: 2014
Antall sider: 320
Forlag: John Wiley and Sons Ltd
Språk: Engelsk
ISBN/EAN: 9780470582299
Kategori: Matematikk
Omtale: Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models
This book provides a user-friendly, hands-on introduction to the Nonlinear Mixed Effects Modeling (NONMEM) system, the most powerful tool for pharmacokinetic / pharmacodynamic analysis. Introduces requisite background to using Nonlinear Mixed Effects Modeling (NONMEM), covering data requirements, model building and evaluation, and quality control aspects Provides examples of nonlinear modeling concepts and estimation basics with discussion on the model building process and applications of empirical Bayesian estimates in the drug development environment Includes detailed chapters on data set structure, developing control streams for modeling and simulation, model applications, interpretation of NONMEM output and results, and quality control Has datasets, programming code, and practice exercises with solutions, available on a supplementary website

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