Generation and Effector Functions of Regulatory Lymphocytes (Innbundet)

Serie: Novartis Foundation Symposia No. 252

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Innbinding: Innbundet
Utgivelsesår: 2003
Antall sider: 326
Forlag: John Wiley and Sons Ltd
Språk: Engelsk
Serie: Novartis Foundation Symposia
Serienummer: No. 252
ISBN/EAN: 9780470850749
Kategori: Naturvitenskap
Omtale: Generation and Effector Functions of Regulatory Lymphocytes
Over the last several years, immunologists have re-discovered the importance of regulatory lymphocytes, formerly termed 'suppressor cells'. Many recent reports have documented their existence, effector functions and potential therapeutic benefits in autoimmunity and transplantation. However, even though modern techniques have allowed us to get a much more detailed picture of these cells, they are still highly controversial. Several unresolved issues responsible for this dilemma are discussed in this book: it is difficult to grow and clone such cells, their phenotypes and effector functions are diverse and can sometimes easily be lost, and it is not well understood how they interact with antigen-presenting cells. This book contains contributions from leading investigators from around the world, including lively discussion of the current state of the art in studies of regulatory lymphocytes. Topics featured are the physiological control of autoimmunity, the role of antigen-specific cells in various diseases and disease models and effector mechanisms. Therapeutic applications are considered, particularly for type 1 diabetes, tissue transplantation and the control of viral infection.
This important and groundbreaking book should be of interest to all immunologists. Related Novartis Foundation symposia: 254 Immunoinformatics: bioinformatic strategies for better understanding of immune function Chair: Hans-Georg Rammensee 256 Cancer and inflammation Chair: Siamon Gordon

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