The extraordinary prize-winning debut from Andrew Miller. Winner of the IMPAC Award and James Tait Black Memorial Prize. At the dawn of the Enlightenment, James Dyer is born unable to feel pain. A source of wonder and scientific curiosity as a child, he rises through the ranks of Georgian society to become a brilliant surgeon. Yet as a human being he fails, for he can no more feel love and compassion than pain. Until, en route to St Petersburg to inoculate the Empress Catherine against smallpox, he meets his nemesis and saviour.